|
Symbol Name ID |
Cr2
complement receptor 2 MGI:88489 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Decreased circulating IgA level |
Chronic partially decreased circulating IgG1 |
Chronic (near) absent circulating IgG4 |
Decreased circulating total IgG |
Reduced isohemagglutinin level |
Decreased specific pneumococcal antibody level |
Leukopenia |
Pericarditis |
Lymphadenopathy |
Splenomegaly |
Lupus nephritis |
Nephritis |
Recurrent urinary tract infections |
Abnormality of the immune system |
Discoid lupus rash |
Malar rash |
Serositis |
Decreased circulating complement C3 concentration |
Decreased circulating complement C4 concentration |
Antineutrophil antibody positivity |
Perinuclear antineutrophil antibody positivity |
Antinuclear antibody positivity |
Anti-dsDNA antibody positivity |
Anti-La/SS-B antibody positivity |
Anti-Sm antibody positivity |
Anti-U1 ribonucleoprotein antibody positivity |
Antiphospholipid antibody positivity |
Systemic lupus erythematosus |
Recurrent infections |
Recurrent respiratory infections |
| Disease(s) Associated with CR2 | ||||||||||||||||||||||||||||||
| common variable immunodeficiency 7 | ||||||||||||||||||||||||||||||
| systemic lupus erythematosus |
| Mouse Phenotypes | immune system phenotype |
abnormal class switch recombination |
abnormal memory B cell differentiation |
decreased neutrophil cell number |
decreased B-1a cell number |
decreased follicular B cell number |
increased marginal zone B cell number |
decreased B cell number |
abnormal B-1 B cell morphology |
abnormal spleen germinal center morphology |
decreased spleen germinal center number |
decreased spleen germinal center size |
abnormal B cell physiology |
abnormal B cell activation |
abnormal germinal center B cell physiology |
decreased IgG1 level |
decreased IgG2a level |
decreased IgG2b level |
decreased IgG2c level |
decreased IgG3 level |
decreased IgG level |
decreased IgM level |
increased IgM level |
decreased immunoglobulin level |
abnormal immune system morphology |
abnormal adaptive immunity |
abnormal humoral immune response |
impaired humoral immune response |
decreased tumor necrosis factor secretion |
increased anti-double stranded DNA antibody level |
increased susceptibility to bacterial infection |
increased susceptibility to bacterial infection induced morbidity/mortality |
|
| Availability | Mouse Genotype | ||||||||||||||||||||||||||||||||
| Cr2M1Btlr/Cr2M1Btlr | |||||||||||||||||||||||||||||||||
| Cr2tm1.1Jhws/Cr2tm1.1Jhws | * | ||||||||||||||||||||||||||||||||
| Cr2tm1Crr/Cr2tm1Crr | * | ||||||||||||||||||||||||||||||||
| Cr2tm1Hmo/Cr2tm1Hmo | |||||||||||||||||||||||||||||||||
| Cr2tm1Tft/Cr2tm1Tft | |||||||||||||||||||||||||||||||||
| Cr2tm2.1(HLA-A)Crr/Cr2tm2.1(HLA-A)Crr | |||||||||||||||||||||||||||||||||
| Cr2tm2.1Jhws/Cr2tm2.1Jhws | * | ||||||||||||||||||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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